The effect of obeticholic acid on hepatic blood flow in isolated, perfused porcine liver: Correction of oxygen‐nutrient mismatch might be a putative mechanism of action in NASH
Abstract Background The liver has a unique dual blood supply. Chronic excess nutrient delivery via the portal vein (PV), unmatched by hepatic artery (HA) oxygen could account for liver damage in NASH. Obeticholic acid (OCA), is a Farnesoid‐X‐receptor agonist with vascular targets in the liver. It ha...
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Wiley,
2022-09-01T00:00:00Z.
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