Glibenclamide-Loaded Nanoparticles Reduce NLRP3 Inflammasome Activation and Modulate miR-223-3p/miR-7-1-5p Expression in THP-1 Cells

• Main Authors: Roberta Mancuso (Author), Lorenzo Agostino Citterio (Author), Simone Agostini (Author), Ivana Marventano (Author), Francesca La Rosa (Author), Francesca Re (Author), Pierfausto Seneci (Author), Marina Saresella (Author), Mario Clerici (Author)
• Format: Book
• Published: MDPI AG, 2023-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The anti-hyperglycemic drug glibenclamide (Glb) might represent an interesting therapeutic option in human neurodegenerative diseases because of its anti-inflammatory activity and its ability to downregulate activation of the NLRP3 inflammasome. Bi-functionalized liposomes that can cross the blood-b...