Myostatin Promotes Osteoclastogenesis by Regulating Ccdc50 Gene Expression and RANKL-Induced NF-κB and MAPK Pathways

• Main Authors: Xin Zhi (Author), Qian Chen (Author), Shaojun Song (Author), Zhengrong Gu (Author), Wenqiang Wei (Author), Huiwen Chen (Author), Xiao Chen (Author), Weizong Weng (Author), Qirong Zhou (Author), Jin Cui (Author), Liehu Cao (Author)
• Format: Book
• Published: Frontiers Media S.A., 2020-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Myostatin is a crucial cytokine that is widely present in skeletal muscle and that negatively regulates the growth and development of muscle cells. Recent research has shown that myostatin might play an essential role in bone metabolism. In RAW264.7 cells and bone marrow monocytes (BMMCs), myostatin...