Synthetic miR-21 decoy circularized by tRNA splicing mechanism inhibited tumorigenesis in glioblastoma in vitro and in vivo models

• Główni autorzy: Hadi Bayat (Autor), Mohammad Hossein Pourgholami (Autor), Saeid Rahmani (Autor), Safura Pournajaf (Autor), Seyed Javad Mowla (Autor)
• Format: Książka
• Wydane: Elsevier, 2023-06-01T00:00:00Z.
• Hasła przedmiotowe: article
• Dostęp online: Connect to this object online.

Glioblastoma multiforme (GBM) is the deadliest primary central nervous system tumor. miRNAs (miRs), a class of non-coding RNAs, are considered pivotal post-transcriptional regulators of cell signaling pathways. miR-21 is a reliable oncogene that promotes tumorigenesis of cancer cells. We first perfo...