Synthetic miR-21 decoy circularized by tRNA splicing mechanism inhibited tumorigenesis in glioblastoma in vitro and in vivo models

Glioblastoma multiforme (GBM) is the deadliest primary central nervous system tumor. miRNAs (miRs), a class of non-coding RNAs, are considered pivotal post-transcriptional regulators of cell signaling pathways. miR-21 is a reliable oncogene that promotes tumorigenesis of cancer cells. We first perfo...

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Main Authors: Hadi Bayat (Author), Mohammad Hossein Pourgholami (Author), Saeid Rahmani (Author), Safura Pournajaf (Author), Seyed Javad Mowla (Author)
Format: Book
Published: Elsevier, 2023-06-01T00:00:00Z.
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