Metformin Alleviates Hepatic Steatosis and Insulin Resistance in a Mouse Model of High-Fat Diet-Induced Nonalcoholic Fatty Liver Disease by Promoting Transcription Factor EB-Dependent Autophagy

• Main Authors: Dan Zhang (Author), Yicheng Ma (Author), Jianjun Liu (Author), Yi Deng (Author), Bo Zhou (Author), Yu Wen (Author), Mingke Li (Author), Daiyan Wen (Author), Yunyan Ying (Author), Sufeng Luo (Author), Chunjing Shi (Author), Guangyu Pu (Author), Yinglei Miao (Author), Chenggang Zou (Author), Yuanli Chen (Author), Lanqing Ma (Author)
• Format: Book
• Published: Frontiers Media S.A., 2021-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Nonalcoholic fatty liver disease (NAFLD) results from an abnormal accumulation of lipids within hepatocytes, and is commonly associated with obesity, insulin resistance, and hyperlipidemia. Metformin is commonly used to treat type 2 diabetes mellitus and, in recent years, it was found to play a pote...