Design and evaluation of magnetic-targeted bilosomal gel for rheumatoid arthritis: flurbiprofen delivery using superparamagnetic iron oxide nanoparticles

• Main Authors: Rayan Y. Mushtaq (Author), Nimbagal Raghavendra Naveen (Author), Krishna Jayanth Rolla (Author), Humood Al Shmrany (Author), Sameer Alshehri (Author), Ahmad Salawi (Author), Mallesh Kurakula (Author), Majed A. Alghamdi (Author), Waleed Y. Rizg (Author), Rana B. Bakhaidar (Author), Walaa A. Abualsunun (Author), Khaled M. Hosny (Author), Abdulmohsin J. Alamoudi (Author)
• Format: Book
• Published: Frontiers Media S.A., 2024-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

IntroductionThe study aimed to systematically enhance the fabrication process of flurbiprofen-loaded bilosomes (FSB) using Quality by Design (QbD) principles and Design of Experiments (DOE). The objective was to develop an optimized formulation with improved entrapment efficiency and targeted drug d...