Biophysical and biochemical characterization of a VHH-based IgG-like bi- and trispecific antibody platform

• Main Authors: Lukas Pekar (Author), Michael Busch (Author), Bernhard Valldorf (Author), Steffen C. Hinz (Author), Lars Toleikis (Author), Simon Krah (Author), Stefan Zielonka (Author)
• Format: Book
• Published: Taylor & Francis Group, 2020-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Here, we report the characterization of a VHH-derived IgG-like bi- and trispecific antibody platform that essentially relies on the replacement of the VH and VL regions of a conventional antibody by two independently functioning VHH domains. Consequently, a VHH is engrafted onto constant region CH1...