Maternal Nicotine Exposure Alters Hippocampal Microglia Polarization and Promotes Anti-inflammatory Signaling in Juvenile Offspring in Mice

• Main Authors: Li Zhou (Author), Xinrong Tao (Author), Gang Pang (Author), Min Mu (Author), Qixian Sun (Author), Fei Liu (Author), Yuting Hu (Author), Huihui Tao (Author), Bing Li (Author), Keyi Xu (Author)
• Format: Book
• Published: Frontiers Media S.A., 2021-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Accumulating evidence reveal that maternal smoking or perinatal nicotine replacement therapy impairs hippocampal neurogenesis, neural development, and cognitive behaviors in the offspring. Microglia is a source of non-neural regulation of neuronal development and postnatal neurogenesis. In this stud...