Honokiol, a Polyphenol Natural Compound, Attenuates Cisplatin-Induced Acute Cytotoxicity in Renal Epithelial Cells Through Cellular Oxidative Stress and Cytoskeleton Modulations

• Main Authors: Tse-En J. Wang (Author), Hung-Ting Liu (Author), Yu-Hua Lai (Author), Tong-Rong Jan (Author), Naohiro Nomura (Author), Hui-Wen Chang (Author), Chi-Chung Chou (Author), Ya-Jane Lee (Author), Pei-Shiue J. Tsai (Author)
• Format: Book
• Published: Frontiers Media S.A., 2018-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Cisplatin is a potent anti-cancer drug that has been widely used in the treatment of various cancers; however, cisplatin administration results in severe nephrotoxicity and impedes its clinical applications. In this study, we showed that honokiol, a polyphenol constituent extracted from Magnolia off...