BRCA1/2 genetic background-based therapeutic tailoring of human ovarian cancer: hope or reality?

• Main Authors: Tagliaferri Pierosandro (Author), Ventura Monica (Author), Baudi Francesco (Author), Cucinotto Iole (Author), Arbitrio Mariamena (Author), Di Martino Maria (Author), Tassone Pierfrancesco (Author)
• Format: Book
• Published: BMC, 2009-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

<p>Abstract</p> <p>Ovarian epithelial tumors are an hallmark of hereditary cancer syndromes which are related to the germ-line inheritance of cancer predisposing mutations in BRCA1 and BRCA2 genes. Although these genes have been associated with multiple different physiologic functi...