Reversal of Vocal Fold Mucosal Fibrosis Using siRNA against the Collagen-Specific Chaperone Serpinh1

• Main Authors: Yo Kishimoto (Author), Masaru Yamashita (Author), Alice Wei (Author), Yutaka Toya (Author), Shuyun Ye (Author), Christina Kendziorski (Author), Nathan V. Welham (Author)
• Format: Book
• Published: Elsevier, 2019-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Vocal fold (VF) mucosal fibrosis results in substantial voice impairment and is recalcitrant to current treatments. To reverse this chronic disorder, anti-fibrotic therapies should target the molecular pathology of aberrant collagen accumulation in the extracellular matrix. We investigated the thera...