Amiodarone hydrochloride: enhancement of solubility and dissolution rate by solid dispersion technique

• Egile Nagusiak: Alexandre Machado Rubim (Egilea), Jaqueline Bandeira Rubenick (Egilea), Eduarda Gregolin (Egilea), Luciane Varini Laporta (Egilea), Rosimar Leitenberg (Egilea), Clarice Madalena Bueno Rolim (Egilea)
• Formatua: Liburua
• Argitaratua: Universidade de São Paulo, 2015-12-01T00:00:00Z.
• Gaiak: article
• Sarrera elektronikoa: Connect to this object online.

abstract Amiodarone HCl is an antiarrhythmic agent, which has low aqueous solubility and presents absorption problems. This study aimed to develop inclusion complexes containing hydrophilic carriers PEG 1500, 4000 and 6000 by fusion and kneading methods in order to evaluate the increase in solubilit...