Amiodarone hydrochloride: enhancement of solubility and dissolution rate by solid dispersion technique

abstract Amiodarone HCl is an antiarrhythmic agent, which has low aqueous solubility and presents absorption problems. This study aimed to develop inclusion complexes containing hydrophilic carriers PEG 1500, 4000 and 6000 by fusion and kneading methods in order to evaluate the increase in solubilit...

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Main Authors: Alexandre Machado Rubim (Author), Jaqueline Bandeira Rubenick (Author), Eduarda Gregolin (Author), Luciane Varini Laporta (Author), Rosimar Leitenberg (Author), Clarice Madalena Bueno Rolim (Author)
Format: Book
Published: Universidade de São Paulo, 2015-12-01T00:00:00Z.
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