Amiodarone hydrochloride: enhancement of solubility and dissolution rate by solid dispersion technique

• मुख्य लेखकों: Alexandre Machado Rubim (लेखक), Jaqueline Bandeira Rubenick (लेखक), Eduarda Gregolin (लेखक), Luciane Varini Laporta (लेखक), Rosimar Leitenberg (लेखक), Clarice Madalena Bueno Rolim (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: Universidade de São Paulo, 2015-12-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

abstract Amiodarone HCl is an antiarrhythmic agent, which has low aqueous solubility and presents absorption problems. This study aimed to develop inclusion complexes containing hydrophilic carriers PEG 1500, 4000 and 6000 by fusion and kneading methods in order to evaluate the increase in solubilit...