MDM2 inhibitor ameliorates cisplatin‐induced nephropathy via NFκΒ signal inhibition

• Main Authors: Tomoyuki Fujikura (Author), Hideo Yasuda (Author), Takamasa Iwakura (Author), Takayuki Tsuji (Author), Hans‐J. Anders (Author)
• Format: Book
• Published: Wiley, 2019-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Cisplatin is a platinum‐containing chemotherapeutic drug, which is widely used and highly effective. While effective against tumors, its use is limited by severe side effects such as nephrotoxicity and bone marrow suppression. Murine double minute 2 (MDM2) is the E3 ubiquitin ligase of the...