Kinetic analysis of ternary and binary binding modes of the bispecific antibody emicizumab

• Autori principali: Stefanie Mak (Autore), Agnes Marszal (Autore), Nena Matscheko (Autore), Ulrich Rant (Autore)
• Natura: Libro
• Pubblicazione: Taylor & Francis Group, 2023-12-01T00:00:00Z.
• Soggetti: article
• Accesso online: Connect to this object online.

ABSTRACTThe binding properties of bispecific antibodies (bsAb) are crucial for their function, especially when two antigens are targeted on the same cell surface. Dynamic interactions between each of the antibody's arms and its cognate target cause the formation and decay of a biologically func...