Development and Application of a Mechanistic Cooling and Freezing Model of the Spin Freezing Step within the Framework of Continuous Freeze-Drying

• Main Authors: Gust Nuytten (Author), Susan Ríos Revatta (Author), Pieter-Jan Van Bockstal (Author), Ashish Kumar (Author), Joris Lammens (Author), Laurens Leys (Author), Brecht Vanbillemont (Author), Jos Corver (Author), Chris Vervaet (Author), Thomas De Beer (Author)
• Format: Book
• Published: MDPI AG, 2021-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

During the spin freezing step of a recently developed continuous spin freeze-drying technology, glass vials are rapidly spun along their longitudinal axis. The aqueous drug formulation subsequently spreads over the inner vial wall, while a cold gas flow is used for cooling and freezing the product....