A Glycoengineered Interferon-β Mutein (R27T) Generates Prolonged Signaling by an Altered Receptor-Binding Kinetics

• Main Authors: Saehyung Lee (Author), Woo Sung Son (Author), Ho Bin Yang (Author), Nirmal Rajasekaran (Author), Sung-Su Kim (Author), Sungyoul Hong (Author), Joon-Seok Choi (Author), Jun Young Choi (Author), Kyoung Song (Author), Young Kee Shin (Author)
• Format: Book
• Published: Frontiers Media S.A., 2019-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The glycoengineering approach is used to improve biophysical properties of protein-based drugs, but its direct impact on binding affinity and kinetic properties for the glycoengineered protein and its binding partner interaction is unclear. Type I interferon (IFN) receptors, composed of IFNAR1 and I...