Toward Optimized ⁸⁹Zr-Immuno-PET: Side-by-Side Comparison of [⁸⁹Zr]Zr-DFO-, [⁸⁹Zr]Zr-3,4,3-(LI-1,2-HOPO)- and [⁸⁹Zr]Zr-DFO*-Cetuximab for Tumor Imaging: Which Chelator Is the Most Suitable?

• Main Authors: Helen Damerow (Author), Xia Cheng (Author), Valeska von Kiedrowski (Author), Ralf Schirrmacher (Author), Björn Wängler (Author), Gert Fricker (Author), Carmen Wängler (Author)
• Format: Book
• Published: MDPI AG, 2022-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

⁸⁹Zr represents a highly favorable positron emitter for application in immuno-PET (Positron Emission Tomography) imaging. Clinically, the ⁸⁹Zr⁴⁺ ion is introduced into antibodies by complexation with desferrioxamine B. However, pro...