Neurorestorative Effects of a Novel Fas-Associated Factor 1 Inhibitor in the MPTP Model: An [18F]FE-PE2I Positron Emission Tomography Analysis Study

• Main Authors: Hyun Soo Park (Author), Yoo Sung Song (Author), Byung Seok Moon (Author), Sung-Eun Yoo (Author), Jae Moon Lee (Author), Yeon-Tae Chung (Author), Eunhee Kim (Author), Byung Chul Lee (Author), Sang Eun Kim (Author)
• Format: Book
• Published: Frontiers Media S.A., 2020-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Fas-associated factor 1 (FAF1), a Fas-binding protein, is implicated in neuronal cell death in Parkinson's disease (PD). We examined the effects of a novel FAF1 inhibitor, KM-819, in dopaminergic neurons in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) mouse model using [18F]FE-PE2I pos...