Synthesis, Physicochemical, Labeling and In Vivo Characterization of ⁴⁴Sc-Labeled DO3AM-NI as a Hypoxia-Sensitive PET Probe

• Ngā kaituhi matua: Dániel Szücs (Author), Tibor Csupász (Author), Judit P. Szabó (Author), Adrienn Kis (Author), Barbara Gyuricza (Author), Viktória Arató (Author), Viktória Forgács (Author), Adrienn Vágner (Author), Gábor Nagy (Author), Ildikó Garai (Author), Dezső Szikra (Author), Imre Tóth (Author), György Trencsényi (Author), Gyula Tircsó (Author), Anikó Fekete (Author)
• Hōputu: Pukapuka
• I whakaputaina: MDPI AG, 2022-05-01T00:00:00Z.
• Ngā marau: article
• Urunga tuihono: Connect to this object online.

Hypoxia promotes angiogenesis, which is crucial for tumor growth, and induces malignant progression and increases the therapeutic resistance. Positron emission tomography (PET) enables the detection of the hypoxic regions in tumors using 2-nitroimidazole-based radiopharmaceuticals. We describe here...