Novel Thiol Containing Hybrid Antioxidant-Nitric Oxide Donor Small Molecules for Treatment of Glaucoma

• Main Authors: Charles E. Amankwa (Author), Sudershan R. Gondi (Author), Adnan Dibas (Author), Courtney Weston (Author), Arlene Funk (Author), Tam Nguyen (Author), Kytai T. Nguyen (Author), Dorette Z. Ellis (Author), Suchismita Acharya (Author)
• Format: Book
• Published: MDPI AG, 2021-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Oxidative stress induced death and dysregulation of trabecular meshwork (TM) cells contribute to the increased intraocular pressure (IOP) in primary open angle (POAG) glaucoma patients. POAG is one of the major causes of irreversible vision loss worldwide. Nitric oxide (NO), a small gas molecule, ha...