Pore dilation occurs in TRPA1 but not in TRPM8 channels

• Main Authors: Faltynek Connie R (Author), Cavanaugh Eric J (Author), Bianchi Bruce R (Author), Kim Donghee (Author), Chen Jun (Author), Kym Philip R (Author), Reilly Regina M (Author)
• Format: Book
• Published: SAGE Publishing, 2009-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

<p>Abstract</p> <p>Abundantly expressed in pain-sensing neurons, TRPV1, TRPA1 and TRPM8 are major cellular sensors of thermal, chemical and mechanical stimuli. The function of these ion channels has been attributed to their selective permeation of small cations (e.g., Ca<sup>...