Astrocyte Activation in Locus Coeruleus Is Involved in Neuropathic Pain Exacerbation Mediated by Maternal Separation and Social Isolation Stress

• Main Authors: Kazuo Nakamoto (Author), Fuka Aizawa (Author), Megumi Kinoshita (Author), Yutaka Koyama (Author), Shogo Tokuyama (Author)
• Formato: Livro
• Publicado em: Frontiers Media S.A., 2017-06-01T00:00:00Z.
• Assuntos: article
• Acesso em linha: Connect to this object online.

Our previous studies demonstrated that emotional dysfunction associated with early life stress exacerbated nerve injury-induced mechanical allodynia. Sex differences were observed in several anxiety tests, but not in mechanical allodynia. To elucidate the mechanism underlying these findings, we have...