Accurate determination of epitope for antibodies with unknown 3D structures

• Main Authors: Shifa Tahir (Author), Thomas Bourquard (Author), Astrid Musnier (Author), Yann Jullian (Author), Yannick Corde (Author), Zakaria Omahdi (Author), Laetitia Mathias (Author), Eric Reiter (Author), Pascale Crépieux (Author), Gilles Bruneau (Author), Anne Poupon (Author)
• Format: Book
• Published: Taylor & Francis Group, 2021-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

MAbTope is a docking-based method for the determination of epitopes. It has been used to successfully determine the epitopes of antibodies with known 3D structures. However, during the antibody discovery process, this structural information is rarely available. Although we already have evidence that...