ALKBH5-mediated m6A mRNA methylation governs human embryonic stem cell cardiac commitment

• Main Authors: Zhenbo Han (Author), Zihang Xu (Author), Ying Yu (Author), Yang Cao (Author), Zhengyi Bao (Author), Xinlu Gao (Author), Danyu Ye (Author), Gege Yan (Author), Rui Gong (Author), Juan Xu (Author), Lai Zhang (Author), Wenya Ma (Author), Xiuxiu Wang (Author), Fan Yang (Author), Hong Lei (Author), Ye Tian (Author), Shijun Hu (Author), Djibril Bamba (Author), Ying Li (Author), Desheng Li (Author), Changzhu Li (Author), Ning Wang (Author), Ying Zhang (Author), Zhenwei Pan (Author), Baofeng Yang (Author), Benzhi Cai (Author)
• Format: Book
• Published: Elsevier, 2021-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

N6-methyladenosine (m6A), as the most abundant modification of mammalian messenger RNAs, is essential for tissue development and pathogenesis. However, the biological significance of m6A methylation in cardiac differentiation and development remains largely unknown. Here, we identify that the downre...