Atypical cholangiocytes derived from hepatocyte-cholangiocyte transdifferentiation mediated by COX-2: a kind of misguided liver regeneration

• Main Authors: Tian Lan (Author), Yang Tai (Author), Chong Zhao (Author), Yang Xiao (Author), Zhu Yang (Author), Linhao Zhang (Author), Can Gan (Author), Wenting Dai (Author), Huan Tong (Author), Chengwei Tang (Author), Zhiyin Huang (Author), Jinhang Gao (Author)
• Format: Book
• Published: BMC, 2023-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Hepatocyte-cholangiocyte transdifferentiation (HCT) is a potential origin of proliferating cholangiocytes in liver regeneration after chronic injury. This study aimed to determine HCT after chronic liver injury, verify the impacts of HCT on liver repair, and avoid harmful regener...