Conventional Pig as Animal Model for Human Renal Drug Excretion Processes: Unravelling the Porcine Renal Function by Use of a Cocktail of Exogenous Markers

• Main Authors: Laura Dhondt (Author), Siska Croubels (Author), Peter De Paepe (Author), Steven C. Wallis (Author), Saurabh Pandey (Author), Jason A. Roberts (Author), Jeffrey Lipman (Author), Pieter De Cock (Author), Mathias Devreese (Author)
• Format: Book
• Published: Frontiers Media S.A., 2020-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Over recent years, pigs have been promoted as potential animal model due to their anatomical and physiological similarities with humans. However, information about the contribution of distinct renal elimination processes [glomerular filtration rate (GFR), effective renal plasma flow (ERPF), tubular...