Discovery of a series of dimethoxybenzene FGFR inhibitors with 5H-pyrrolo[2,3-b]pyrazine scaffold: structure-activity relationship, crystal structural characterization and in vivo study

• Main Authors: Peng Wei (Author), Bo Liu (Author), Ruifeng Wang (Author), Yinglei Gao (Author), Lanlan Li (Author), Yuchi Ma (Author), Zhiwei Qian (Author), Yuelei Chen (Author), Maosheng Cheng (Author), Meiyu Geng (Author), Jingkang Shen (Author), Dongmei Zhao (Author), Jing Ai (Author), Bing Xiong (Author)
• Format: Book
• Published: Elsevier, 2019-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Genomic alterations are commonly found in the signaling pathways of fibroblast growth factor receptors (FGFRs). Although there is no selective FGFR inhibitors in market, several promising inhibitors have been investigated in clinical trials, and showed encouraging efficacies in patients. By designin...