Discovery of a series of dimethoxybenzene FGFR inhibitors with 5H-pyrrolo[2,3-b]pyrazine scaffold: structure-activity relationship, crystal structural characterization and in vivo study

• Үндсэн зохиолчид: Peng Wei (Зохиогч), Bo Liu (Зохиогч), Ruifeng Wang (Зохиогч), Yinglei Gao (Зохиогч), Lanlan Li (Зохиогч), Yuchi Ma (Зохиогч), Zhiwei Qian (Зохиогч), Yuelei Chen (Зохиогч), Maosheng Cheng (Зохиогч), Meiyu Geng (Зохиогч), Jingkang Shen (Зохиогч), Dongmei Zhao (Зохиогч), Jing Ai (Зохиогч), Bing Xiong (Зохиогч)
• Формат: Ном
• Хэвлэсэн: Elsevier, 2019-03-01T00:00:00Z.
• Нөхцлүүд: article
• Онлайн хандалт: Connect to this object online.

Genomic alterations are commonly found in the signaling pathways of fibroblast growth factor receptors (FGFRs). Although there is no selective FGFR inhibitors in market, several promising inhibitors have been investigated in clinical trials, and showed encouraging efficacies in patients. By designin...