Antihistamines suppress upregulation of histidine decarboxylase gene expression with potencies different from their binding affinities for histamine H1 receptor in toluene 2,4-diisocyanate-sensitized rats

• Main Authors: Hiroyuki Mizuguchi (Author), Asish K. Das (Author), Kazutaka Maeyama (Author), Shrabanti Dev (Author), Masum Shahriar (Author), Yoshiaki Kitamura (Author), Noriaki Takeda (Author), Hiroyuki Fukui (Author)
• Format: Book
• Published: Elsevier, 2016-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Antihistamines inhibit histamine signaling by blocking histamine H1 receptor (H1R) or suppressing H1R signaling as inverse agonists. The H1R gene is upregulated in patients with pollinosis, and its expression level is correlated with the severity of nasal symptoms. Here, we show that antihistamine s...