A multicompartment population PK model to predict tenofovir and emtricitabine mucosal tissue concentrations for HIV prevention

• Главные авторы: Erick Leung (Автор), Mackenzie L. Cottrell (Автор), Craig Sykes (Автор), Nicole White (Автор), Angela D. M. Kashuba (Автор), Julie B. Dumond (Автор)
• Формат: ‌
• Опубликовано: Wiley, 2023-12-01T00:00:00Z.
• Предметы: article
• Online-ссылка: Connect to this object online.

Abstract A priori use of mathematical modeling and simulation to predict outcomes from incomplete adherence or reduced frequency dosing strategies may mitigate the risk of clinical trial failure with HIV pre‐exposure prophylaxis regimens. We developed a semi‐physiologic population pharmacokinetic mo...