Pharmacokinetics and Pharmacodynamics of a 13-mer LNA-inhibitor-miR-221 in Mice and Non-human Primates

• Main Authors: Maria Eugenia Gallo Cantafio (Author), Boye Schnack Nielsen (Author), Chiara Mignogna (Author), Mariamena Arbitrio (Author), Cirino Botta (Author), Niels M Frandsen (Author), Christian Rolfo (Author), Pierosandro Tagliaferri (Author), Pierfrancesco Tassone (Author), Maria Teresa Di Martino (Author)
• Format: Book
• Published: Elsevier, 2016-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Locked nucleic acid (LNA) oligonucleotides have been successfully used to efficiently inhibit endogenous small noncoding RNAs in vitro and in vivo. We previously demonstrated that the direct miR-221 inhibition by the novel 13-mer LNA-i-miR-221 induces significant antimyeloma activity and upregulates...