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A high-dose inoculum size results in persistent viral infection and arthritis in mice infected with chikungunya virus.

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Chikungunya virus (CHIKV) is an emerging mosquito-transmitted alphavirus that leads to acute fever and chronic debilitating polyarthralgia. To date, the mechanism underlying chronic recurrent arthralgia is unknown. In the present study, newborn wild-type C57BL/6 mice were infected with CHIKV, and th...

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Main Authors: Yue Zhang (Author), Hu Yan (Author), Xian Li (Author), Dihan Zhou (Author), Maohua Zhong (Author), Jingyi Yang (Author), Bali Zhao (Author), Xuxu Fan (Author), Jun Fan (Author), Jiayi Shu (Author), Mengji Lu (Author), Xia Jin (Author), Ejuan Zhang (Author), Huimin Yan (Author)
Format: Book
Published: Public Library of Science (PLoS), 2022-01-01T00:00:00Z.
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3rd Floor Main Library

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