Ginkgo biloba leaf extract mitigates cisplatin-induced chronic renal interstitial fibrosis by inhibiting the epithelial-mesenchymal transition of renal tubular epithelial cells mediated by the Smad3/TGF-β1 and Smad3/p38 MAPK pathways

Ginkgo biloba leaf extract mitigates cisplatin-induced chronic renal interstitial fibrosis by inhibiting the epithelial-mesenchymal transition of renal tubular epithelial cells mediated by the Smad3/TGF-β1 and Smad3/p38 MAPK pathways

Abstract Background Our previous study indicated that Ginkgo biloba leaf extract (EGb) could protect against cisplatin-induced acute kidney injury in rabbits. The present study aimed to determine the effects and potential molecular mechanisms of EGb on chronic renal interstitial fibrosis induced by...

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Main Authors: Congying Wei (Author), Yansong Zhang (Author), Xiaobin Zhong (Author), Sisi Lu (Author), Xiaoqin Zou (Author), Yufang Yang (Author), Songqing Huang (Author), Zhenguang Huang (Author)
Format: Book
Published: BMC, 2022-02-01T00:00:00Z.
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