Cover Image

Ginkgo biloba leaf extract mitigates cisplatin-induced chronic renal interstitial fibrosis by inhibiting the epithelial-mesenchymal transition of renal tubular epithelial cells mediated by the Smad3/TGF-β1 and Smad3/p38 MAPK pathways

Abstract Background Our previous study indicated that Ginkgo biloba leaf extract (EGb) could protect against cisplatin-induced acute kidney injury in rabbits. The present study aimed to determine the effects and potential molecular mechanisms of EGb on chronic renal interstitial fibrosis induced by...

Full description

Saved in:

Bibliographic Details
Main Authors:	Congying Wei (Author), Yansong Zhang (Author), Xiaobin Zhong (Author), Sisi Lu (Author), Xiaoqin Zou (Author), Yufang Yang (Author), Songqing Huang (Author), Zhenguang Huang (Author)
Format:	Book
Published:	BMC, 2022-02-01T00:00:00Z.
Subjects:	article
Online Access:	Connect to this object online.
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

Targeting SMAD-Dependent Signaling: Considerations in Epithelial and Mesenchymal Solid Tumors
by: Farhana Runa, et al.
Published: (2024)

Baicalin protects against renal interstitial fibrosis in mice by inhibiting the TGF-β/Smad signalling pathway
by: Hui Wang, et al.
Published: (2022)

Renal tubular epithelial cell quality control mechanisms as therapeutic targets in renal fibrosis
by: Yini Bao, et al.
Published: (2024)

CRTC2 activates the epithelial-mesenchymal transition of diabetic kidney disease through the CREB-Smad2/3 pathway
by: Yujie Li, et al.
Published: (2023)

Protective Effect of Znt7 on High Glucose-Induced Epithelial-to-Mesenchymal Transition in Renal Tubular Epithelial Cells
by: Xiuli Zhang, et al.
Published: (2018)

Sasanquasaponin inhibited epithelial to mesenchymal transition in prostate cancer by regulating the PI3K/Akt/mTOR and Smad pathways
by: Wenfeng Li, et al.
Published: (2022)

High SMAD7 and p-SMAD2,3 expression is associated with environmental enteropathy in children.
by: Sana Syed, et al.
Published: (2018)

Effect of aging on the formation and growth of colonic epithelial organoids by changes in cell cycle arrest through TGF-β-Smad3 signaling
by: Min Kyoung Jo, et al.
Published: (2023)

Myricitrin inhibited ferritinophagy-mediated ferroptosis in cisplatin-induced human renal tubular epithelial cell injury
by: Jiawen Lin, et al.
Published: (2024)

Micheliolide Attenuates Lipopolysaccharide-Induced Inflammation by Modulating the mROS/NF-κB/NLRP3 Axis in Renal Tubular Epithelial Cells
by: Xianghong Lei, et al.
Published: (2020)

Salidroside protects renal tubular epithelial cells from hypoxia/reoxygenation injury in vitro
by: Yan Sun, et al.
Published: (2018)

Roles of renal tubular epithelial cell injury related cytokines in chronic kidney disease
by: Chuan-ling Wang, et al.
Published: (2024)

Mechanism of miRNA-141-3p in calcium oxalate-induced renal tubular epithelial cell injury via NLRP3-mediated pyroptosis
by: Xiu-Guo Gan, et al.
Published: (2022)

Assessment of the Role of Selected SMAD3 and SMAD4 Genes Polymorphisms in the Development of Colorectal Cancer: Preliminary Research
by: Wosiak A, et al.
Published: (2021)

<i>Ginkgo biloba</i> Extract Stimulates Adipogenesis in 3T3-L1 Preadipocytes
by: Fernanda Malanconi Thomaz, et al.
Published: (2022)

Resveratrol inhibits transforming growth factor-β2-induced epithelial-to-mesenchymal transition in human retinal pigment epithelial cells by suppressing the Smad pathway
by: Chen CL, et al.
Published: (2017)

Quercetin inhibits transforming growth factor β1-induced epithelial–mesenchymal transition in human retinal pigment epithelial cells via the Smad pathway
by: Cai W, et al.
Published: (2018)

<i>Cinnamomum bejolghota</i> Extract Inhibits Colorectal Cancer Cell Metastasis and TGF-β1-Induced Epithelial-Mesenchymal Transition via Smad and Non-Smad Signaling Pathway
by: Athicha Kittiwattanokhun, et al.
Published: (2022)

FoxM1 inhibition ameliorates renal interstitial fibrosis by decreasing extracellular matrix and epithelial-mesenchymal transition
by: Yanhui Wang, et al.
Published: (2020)

TGF-β1/Smads and miR-21 in Renal Fibrosis and Inflammation
by: Agnieszka Loboda, et al.
Published: (2016)

Swainsonine Triggers Paraptosis via ER Stress and MAPK Signaling Pathway in Rat Primary Renal Tubular Epithelial Cells
by: Shuai Wang, et al.
Published: (2021)

Estaquia de Ginkgo biloba L. utilizando três substratos Ginkgo biloba L. cutting using three substrates
by: J Bitencourt, et al.
Published: (2010)

SENP3 Aggravates Renal Tubular Epithelial Cell Apoptosis in Lipopolysaccharide-Induced Acute Kidney Injury via deSUMOylation of Drp1
by: Lirui Wang, et al.
Published: (2022)

Icariin inhibits epithelial mesenchymal transition of renal tubular epithelial cells via regulating the miR-122-5p/FOXP2 axis in diabetic nephropathy rats
by: Li Zang, et al.
Published: (2022)

Isoliensinine Attenuates Renal Fibrosis and Inhibits TGF-β1/Smad2/3 Signaling Pathway in Spontaneously Hypertensive Rats
by: Yao M, et al.
Published: (2023)

Efficacy of Oroxylin A in ameliorating renal fibrosis with emphasis on Sirt1 activation and TGF-β/Smad3 pathway modulation
by: Guangzhuang Li, et al.
Published: (2024)

The flavonoid fisetin ameliorates renal fibrosis by inhibiting SMAD3 phosphorylation, oxidative damage, and inflammation in ureteral obstructed kidney in mice
by: Ha Young Ju, et al.
Published: (2023)

Effect of Sedum sarmentosum Bunge Extract on Aristolochic Acid- Induced Renal Tubular Epithelial Cell Injury
by: Yongheng Bai, et al.
Published: (2014)

Gremlin Regulates Tubular Epithelial to Mesenchymal Transition via VEGFR2: Potential Role in Renal Fibrosis
by: Laura Marquez-Exposito, et al.
Published: (2018)

Effect of fluid shear stress on the internalization of kidney-targeted delivery systems in renal tubular epithelial cells
by: Yingying Xu, et al.
Published: (2020)

Effects and Mechanism of Salvianolic Acid B on the Injury of Human Renal Tubular Epithelial Cells Induced by Iopromide
by: Shu-Jun Dong, et al.
Published: (2021)

Crotamine/siRNA Nanocomplexes for Functional Downregulation of Syndecan-1 in Renal Proximal Tubular Epithelial Cells
by: Joana D'Arc Campeiro, et al.
Published: (2023)

Effect of active vitamin D on renin in renal tubular epithelial cells under high glucose conditions
by: Yi-qing He, et al.
Published: (2024)

The Relationship Between Single Nucleotide Polymorphisms of SMAD3/SMAD6 and Risk of Esophageal Squamous Cell Carcinoma in Chinese Population
by: Yu J, et al.
Published: (2020)

Endophytes from Ginkgo biloba and their secondary metabolites
by: Zhihui Yuan, et al.
Published: (2019)

Effect of berberine on the renal tubular epithelial-to-mesenchymal transition by inhibition of the Notch/snail pathway in diabetic nephropathy model KKAy mice
by: Yang GN, et al.
Published: (2017)

MicroRNA-145-5p regulates the proliferation of epithelial ovarian cancer cells via targeting SMAD4
by: Jie Zhou, et al.
Published: (2020)

Gonadotropin releasing hormone analogue (GnRHa) alters the expression and activation of Smad in human endometrial epithelial and stromal cells
by: Xu Jingxia, et al.
Published: (2003)

Arecoline suppresses epithelial cell viability by upregulating tropomyosin-1 through the transforming growth factor-β/Smad pathway
by: Long Li, et al.
Published: (2020)

Expression and possible role of Smad3 in postnecrotizing enterocolitis stricture
by: Rui Chen, et al.
Published: (2022)