Synthesis, biological and computational evaluation of novel cyanomethyl vinyl ether derivatives

• Main Authors: Endika Martín-Encinas (Author), María Fuertes (Author), Samuel Delgado-Hernández (Author), Fernando García-Tellado (Author), David Tejedor (Author), Concepción Alonso (Author)
• Format: Book
• Published: Frontiers Media S.A., 2024-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

This work explores the biological evaluation of novel cyanomethyl vinyl ether derivatives as antiproliferative agents. Tubulin, crucial to microtubule structure and function, is a target for cancer therapies. In vitro cytotoxicity assessments revealed significant activity in SKOV3 ovarian carcinoma...