Dual effect of reduced type I diacylglycerol kinase activity on insulin secretion from MIN6 β-cells

• मुख्य लेखकों: Toshiaki Sawatani (लेखक), Yukiko K. Kaneko (लेखक), Tomohisa Ishikawa (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: Elsevier, 2019-06-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

The role of type I diacylglycerol kinases (DGKs) in the regulation of insulin secretion was investigated in MIN6 β-cells. In intracellular Ca2+ concentration ([Ca2+]i) measurement experiments, 1 μM R59949, a type I DGK inhibitor, and 10 μM DiC8, a diacylglycerol (DAG) analog, amplified 22.2 mM gluco...