Dual effect of reduced type I diacylglycerol kinase activity on insulin secretion from MIN6 β-cells

• Main Authors: Toshiaki Sawatani (Author), Yukiko K. Kaneko (Author), Tomohisa Ishikawa (Author)
• 格式: 圖書
• 出版: Elsevier, 2019-06-01T00:00:00Z.
• 主題: article
• 在線閱讀: Connect to this object online.

The role of type I diacylglycerol kinases (DGKs) in the regulation of insulin secretion was investigated in MIN6 β-cells. In intracellular Ca2+ concentration ([Ca2+]i) measurement experiments, 1 μM R59949, a type I DGK inhibitor, and 10 μM DiC8, a diacylglycerol (DAG) analog, amplified 22.2 mM gluco...