Genome mining of sulfonated lanthipeptides reveals unique cyclic peptide sulfotransferases

• Main Authors: Meng Wang (Author), Wen-Wei Li (Author), Zhe Cao (Author), Jianong Sun (Author), Jiang Xiong (Author), Si-Qin Tao (Author), Tinghong Lv (Author), Kun Gao (Author), Shangwen Luo (Author), Shi-Hui Dong (Author)
• Format: Book
• Published: Elsevier, 2024-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Although sulfonation plays crucial roles in various biological processes and is frequently utilized in medicinal chemistry to improve water solubility and chemical diversity of drug leads, it is rare and underexplored in ribosomally synthesized and post-translationally modified peptides (RiPPs). Bios...