Increased hemoglobin and heme in MALDI-TOF MS analysis induce ferroptosis and promote degeneration of herniated human nucleus pulposus

• Main Authors: Liang Shan (Author), Ximing Xu (Author), Jing Zhang (Author), Peng Cai (Author), Han Gao (Author), Yingjie Lu (Author), Jiangang Shi (Author), Yinlong Guo (Author), Yue Su (Author)
• Format: Book
• Published: BMC, 2021-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Neovasculogenesis is characteristic of herniated lumbar discs, in which extruded nucleus pulposus is prone to heme iron-induced cytotoxicity (increased oxidative stress causing ferroptosis). However, recent analyses of neovascularization are very complicated, and the mechanism of...