PRDX1 Cys52Ser variant alleviates nonalcoholic steatohepatitis by reducing inflammation in mice

• Main Authors: Zhonghao Bai (Author), Wen Yin (Author), Rui Liu (Author), Minglei Tang (Author), Xiaofeng Shi (Author), Cheng Luo (Author), Xiangyang Xie (Author)
• Format: Book
• Published: Elsevier, 2023-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Peroxiredoxin 1 (PRDX1) is a peroxidase and guards against oxidative stress by scavenging intracellular peroxides, whereas it also has been shown to stimulate inflammatory response by functioning as a chaperone protein. The potential in vivo link between PRDX1's peroxidase activity a...