High-throughput discovery of highly selective reversible hMAO-B inhibitors based on at-line nanofractionation

• Hoofdauteurs: Yu Fan (Auteur), Jincai Wang (Auteur), Jingyi Jian (Auteur), Yalei Wen (Auteur), Jiahao Li (Auteur), Hao Tian (Auteur), Jacques Crommen (Auteur), Wei Bi (Auteur), Tingting Zhang (Auteur), Zhengjin Jiang (Auteur)
• Formaat: Boek
• Gepubliceerd in: Elsevier, 2024-04-01T00:00:00Z.
• Onderwerpen: article
• Online toegang: Connect to this object online.

Human monoamine oxidase B (hMAO-B) has emerged as a pivotal therapeutic target for Parkinson's disease. Due to adverse effects and shortage of commercial drugs, there is a need for novel, highly selective, and reversible hMAO-B inhibitors with good blood-brain barrier permeability. In this stud...