High-throughput discovery of highly selective reversible hMAO-B inhibitors based on at-line nanofractionation

Human monoamine oxidase B (hMAO-B) has emerged as a pivotal therapeutic target for Parkinson's disease. Due to adverse effects and shortage of commercial drugs, there is a need for novel, highly selective, and reversible hMAO-B inhibitors with good blood-brain barrier permeability. In this stud...

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Main Authors: Yu Fan (Author), Jincai Wang (Author), Jingyi Jian (Author), Yalei Wen (Author), Jiahao Li (Author), Hao Tian (Author), Jacques Crommen (Author), Wei Bi (Author), Tingting Zhang (Author), Zhengjin Jiang (Author)
Format: Book
Published: Elsevier, 2024-04-01T00:00:00Z.
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