Microneedle-enhanced drug delivery: fabrication, characterization, and insights into release and permeation of nanocrystalline imiquimod

• Main Authors: Sophie Luise Meiser (Author), Jonas Pielenhofer (Author), Ann-Kathrin Hartmann (Author), Lara Stein (Author), Jule Dettweiler (Author), Stephan Grabbe (Author), Markus P. Radsak (Author), Peter Langguth (Author)
• Format: Book
• Published: Frontiers Media S.A., 2024-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Transcutaneous delivery systems bear several advantages over conventional needle-based injections. Considering the low bioavailability and poor water-solubility of imiquimod, a manufacturing process has been developed to incorporate imiquimod as suspended nanocrystals in different formulations. In t...