Microneedle-enhanced drug delivery: fabrication, characterization, and insights into release and permeation of nanocrystalline imiquimod

• Egile Nagusiak: Sophie Luise Meiser (Egilea), Jonas Pielenhofer (Egilea), Ann-Kathrin Hartmann (Egilea), Lara Stein (Egilea), Jule Dettweiler (Egilea), Stephan Grabbe (Egilea), Markus P. Radsak (Egilea), Peter Langguth (Egilea)
• Formatua: Liburua
• Argitaratua: Frontiers Media S.A., 2024-06-01T00:00:00Z.
• Gaiak: article
• Sarrera elektronikoa: Connect to this object online.

Transcutaneous delivery systems bear several advantages over conventional needle-based injections. Considering the low bioavailability and poor water-solubility of imiquimod, a manufacturing process has been developed to incorporate imiquimod as suspended nanocrystals in different formulations. In t...