C188-9, a specific inhibitor of STAT3 signaling, prevents thermal burn-induced skeletal muscle wasting in mice

• Main Authors: Yuko Ono (Author), Masafumi Saito (Author), Kazuho Sakamoto (Author), Yuko Maejima (Author), Shingen Misaka (Author), Kenju Shimomura (Author), Nobuto Nakanishi (Author), Shigeaki Inoue (Author), Joji Kotani (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Burn injury is the leading cause of death and disability worldwide and places a tremendous economic burden on society. Systemic inflammatory responses induced by thermal burn injury can cause muscle wasting, a severe involuntary loss of skeletal muscle that adversely affects the survival and functio...