<i>N</i>-Acetyl-Cysteine Regenerates Albumin Cys34 by a Thiol-Disulfide Breaking Mechanism: An Explanation of Its Extracellular Antioxidant Activity

• Egile Nagusiak: Alessandra Altomare (Egilea), Giovanna Baron (Egilea), Maura Brioschi (Egilea), Martina Longoni (Egilea), Riccardo Butti (Egilea), Edoardo Valvassori (Egilea), Elena Tremoli (Egilea), Marina Carini (Egilea), Piergiuseppe Agostoni (Egilea), Giulio Vistoli (Egilea), Cristina Banfi (Egilea), Giancarlo Aldini (Egilea)
• Formatua: Liburua
• Argitaratua: MDPI AG, 2020-04-01T00:00:00Z.
• Gaiak: article
• Sarrera elektronikoa: Connect to this object online.

In the present paper, the extracellular antioxidant activity of <i>N</i>-acetyl-cysteine (NAC) is explained by considering its ability to regenerate the free form of albumin Cys34 by breaking the disulfide bond of the cysteinylated form (HSA-Cys). NAC's capability to regenerate albu...