Enhanced Levels of Peroxisome-Derived H₂O₂ Do Not Induce Pexophagy but Impair Autophagic Flux in HEK-293 and HeLa Cells

• Main Authors: Hongli Li (Author), Celien Lismont (Author), Cláudio F. Costa (Author), Mohamed A. F. Hussein (Author), Myriam Baes (Author), Marc Fransen (Author)
• Format: Book
• Published: MDPI AG, 2023-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Peroxisomes are functionally specialized organelles that harbor multiple hydrogen peroxide (H₂O₂)-producing and -degrading enzymes. Given that this oxidant functions as a major redox signaling agent, peroxisomes have the intrinsic ability to mediate and...