Choosing an Optimal Solvent Is Crucial for Obtaining Cell-Penetrating Peptide Nanoparticles with Desired Properties and High Activity in Nucleic Acid Delivery

• Main Authors: Abhijit Biswas (Author), Maria Maloverjan (Author), Kärt Padari (Author), Aare Abroi (Author), Margus Rätsep (Author), Sebastian K. T. S. Wärmländer (Author), Jüri Jarvet (Author), Astrid Gräslund (Author), Vambola Kisand (Author), Rünno Lõhmus (Author), Margus Pooga (Author)
• Format: Book
• Published: MDPI AG, 2023-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Cell-penetrating peptides (CPPs) are highly promising transfection agents that can deliver various compounds into living cells, including nucleic acids (NAs). Positively charged CPPs can form non-covalent complexes with negatively charged NAs, enabling simple and time-efficient nanoparticle preparat...