Virtual screening and drug repositioning of FDA-approved drugs from the ZINC database to identify the potential hTERT inhibitors

• Main Authors: Hasan Afzaal (Author), Reem Altaf (Author), Umair Ilyas (Author), Shaiq Uz Zaman (Author), Syed Damin Abbas Hamdani (Author), Saifullah Khan (Author), Hajra Zafar (Author), Mustafeez Mujtaba Babar (Author), Yongtao Duan (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The length of the telomeres is maintained with the help of the enzyme telomerase constituting of two components, namely, a core reverse transcriptase protein (hTERT) and RNA (hTR). It serves as a significant and universal cancer target. In silico approaches play a crucial role in accelerating drug d...