A Modification-Specific Peptide-Based immunization Approach Using CRM197 Carrier Protein: Development of a Selective Vaccine Against Pyroglutamate Aβ Peptides

• Main Authors: Valérie Vingtdeux (Author), Haitian Zhao (Author), Pallavi Chandakkar (Author), Christopher M Acker (Author), Peter Davies (Author), Philippe Marambaud (Author)
• Format: Book
• Published: BMC, 2016-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Strategies aimed at reducing cerebral accumulation of the amyloid-β (Aβ) peptides have therapeutic potential in Alzheimer's disease (AD). Aβ immunization has proven to be effective at promoting Aβ clearance in animal models, but adverse effects have hampered its clinical evaluation. Th...