Fibroblast Growth Factor-2 Suppresses Oridonin-Induced L929 Apoptosis Through Extracellular Signal-Regulated Kinase-Dependent and Phosphatidylinositol 3-Kinase-Independent Pathway

Oridonin, isolated from Rabdosia rubescences, has been reported to exert cytotoxic effects on L929 cells. In this study, we investigated the mechanisms of FGF-2 protection of L929 cells from oridonin-induced apoptosis. Phosphatidylinositol 3-kinase (PI3K)/protein kinase B (PKB) signal did not mediat...

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Main Authors: Jian Huang (Author), Lijun Wu (Author), Shin-ichi Tashiro (Author), Satoshi Onodera (Author), Takashi Ikejima (Author)
Format: Book
Published: Elsevier, 2006-01-01T00:00:00Z.
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