Rhizoma coptidis Inhibits LPS-Induced MCP-1/CCL2 Production in Murine Macrophages via an AP-1 and NF𝜅B-Dependent Pathway

• Main Authors: Andrew Remppis (Author), Florian Bea (Author), Henry Johannes Greten (Author), Annette Buttler (Author), Hongjie Wang (Author), Qianxing Zhou (Author), Michael R. Preusch (Author), Ronny Enk (Author), Robert Ehehalt (Author), Hugo Katus (Author), Erwin Blessing (Author)
• Format: Book
• Published: Hindawi Limited, 2010-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Introduction. The Chinese extract Rhizoma coptidis is well known for its anti-inflammatory, antioxidative, antiviral, and antimicrobial activity. The exact mechanisms of action are not fully understood. Methods. We examined the effect of the extract and its main compound, berberine, on LPS-induced i...