Imaging of fibrogenesis in the liver by [18F]TZ-Z09591, an Affibody molecule targeting platelet derived growth factor receptor β

• Main Authors: Olivia Wegrzyniak (Author), Bo Zhang (Author), Johanna Rokka (Author), Maria Rosestedt (Author), Bogdan Mitran (Author), Pierre Cheung (Author), Emmi Puuvuori (Author), Sofie Ingvast (Author), Jonas Persson (Author), Helena Nordström (Author), John Löfblom (Author), Fredrik Pontén (Author), Fredrik Y. Frejd (Author), Olle Korsgren (Author), Jonas Eriksson (Author), Olof Eriksson (Author)
• Format: Book
• Published: SpringerOpen, 2023-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Platelet-derived growth factor receptor beta (PDGFRβ) is a receptor overexpressed on activated hepatic stellate cells (aHSCs). Positron emission tomography (PET) imaging of PDGFRβ could potentially allow the quantification of fibrogenesis in fibrotic livers. This study aims to ev...